A curved host and second guest cooperatively inhibit the dynamic motion of corannulene

Abstract Biomolecular systems show how host–guest binding can induce changes in molecular behavior, which turn impact the functions of system. Here we report an artificial system where dynamic adaptation during guest alters both host conformation and dynamics. The self-assembled cage employed here possesses concave walls a chirotopic cavity. Complementarity between curved surfaces fullerenes inner surface cavity leads to reconfigure stereochemically order bind these guests optimally. molecule corannulene undergoes rapid bowl-to-bowl inversion at room temperature. Its barrier is increased upon binding, however, further formation ternary complex, cycloalkane are bound together. chiral nature also clear differences NMR spectra complexes involving one or other enantiomer guest, enables determination enantiomeric excess by NMR.